ATM and neoplasm: Analyzing this relationship in proteomic data from patient-derived xenografts (PDX) from immunocompromised NOD/SCID mice that lack mature T cells, B cells, and NK cells, we found that all three detectable cytokines (CCL5, CXCL10, and IL16) positively correlated with levels of phosphorylated ATM (Fig. 5c), suggesting these factors are tumor-cell derived19.