In the absence of Wnt ligand stimulation, cytoplasmic β-catenin is targeted for proteolysis by a “destruction complex”, which includes the two tumor suppressors Axin and Adenomatous polyposis coli (APC), and two kinases, glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α). This evidence concerns the gene AXIN1 and neoplasm.