Further, these findings suggest that the human homolog of Ebd, Jerky (also known as JRK or JH8) [177,179,180,181,182,183,184], and the human homolog of Ewg, Nuclear respiratory Factor 1 (NRF1) [178,185,186,187], may provide promising drug targets for the treatment of Wnt-driven cancers. The gene discussed is NRF1; the disease is cancer.