CDKN2A and mesothelioma: To uncouple the inhibition of cell cycle from upstream events of DNA damage response we utilized ectopic expression of tetracycline-regulatable inhibitor of cyclin-dependent kinases p16ink4a (p16) in human mesothelioma H28 cells in comparison to ectopic expression of p21waf1 (p21) known to induce DNA damage response [50].