TNF and infection: The GSEA results (Fig. 2A; see Table S4 in the supplemental material) showed strongest enrichment in the genes upregulated in both the RH-WT and RHΔmyr1 infections for the set of genes previously shown to be altered by tumor necrosis factor alpha (TNF-α) signaling and entirely consistent with the action of the MYR1-independent GRA15 (22, 32).