A rise of cleaved SphK2 (Fig. 4c) was observed in nuclear fractions (F(1,28) = 10.4; p = 0.003) and in cytoplasmic fractions (F(1,28) = 3.9; p = 0.050) in AD group relative to control group especially in frontal cortex (nuclear p = 0.0015 et cytoplasmic p = 0.08; Fig. 4c1). This evidence concerns the gene SPHK2 and Alzheimer disease.