Here, we evaluated the clinical and histomorphologic features and expression patterns of mTOR, phosphorylated STAT3 (pSTAT3), phosphorylated ERK (pERK) and estrogen-receptor α in hepatocytes and hepatic stellate cells in liver tissue from patients with hepatic steatosis, along with a control group (biliary cysts and hepatolithiasis). This evidence concerns the gene ESR1 and Hepatic steatosis.