As previously shown for malignant melanoma and prostate cancer cells [13], the receptor of the urokinase-plasminogen-activator (uPAR, CD87), is indispensable for ECs and ECFCs to perform an efficient amoeboid angiogenesis, in terms of cell migration and capillary morphogenesis in vitro and in vessel formation within Matrigel plugs in mice. The gene discussed is PLAUR; the disease is prostate cancer.