CD274 and metastatic malignant neoplasm in the lymph nodes: However, although multivariate analysis showed that lymph node metastases were an independent poor prognostic factor (p = 0.046, HR = 4.330), PD-1 and PD-L1 expressions were not independent prognostic factors (p = 0.492, HR = 1.415) (p = 0.084, HR = 2.613) (Table 2).