Recently, our findings further validated the benefits of honokiol on autophagic injury to neuroblastoma cells and glioma cells, and the molecular mechanisms occur via the p53/phosphatydilinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway [17, 18]. This evidence concerns the gene AKT1 and central nervous system cancer.