Interestingly, dormant GBM cells are hallmarked by the upregulation of specific genes like angiomotin, ephrin type-A receptor 5 (EphA5), insulin-like growth factor-binding protein 5 (IGFBP5), and histone cluster 1 (H2BK) [24, 25]. The gene discussed is EPHA5; the disease is glioblastoma.