CD8A and metastatic neoplasm: Furthermore, the number of CD4+, CD8+ and FOXP3+ TILs in the primary tumor was also significantly associated with these numbers in the metastatic tumor (r = 0.634, p = 0.001; r = 0.700, p < 0.001; r = 0.559, p = 0.006, respectively) (Fig. 4).