ELN and Werner syndrome: We chose arteriopathy as a phenotype-of-interest because there is substantial a priori evidence implicating a particular gene in the 7q11.23 WS locus, namely elastin (ELN); hemideletions, translocations, gross deletions, and point mutations of ELN alone, can cause SVAS in an autosomal dominant fashion in individuals who do not have WS [4, 10].