Similar to our previous study showing that bvPLA2 was effective in decreasing Th2 cytokine expression in an asthma mouse model [22], treatment of WT mice with bvPLA2 following DFE/DNCB exposure significantly decreased the expression of Th1 and Th2 cytokines including IFN-γ, IL-4, IL-6, and IL-10. This evidence concerns the gene IL4 and asthma.