More recently, Ao et al. reported that prostatic CAFs express high levels of stromal cell-derived factor-1 (also known as chemokine (C-X-C motif) ligand 12), and the stromal cell-derived factor-1/CXCR4 pathway between cancer cells and stromal cells could be involved in tumorigenesis of PCa [135]. This evidence concerns the gene CXCL12 and cancer.