They also showed that the adhesion of T cells to synovial cells was inhibited by a murine anti-VCAM-1 monoclonal antibody (BBA6) or anti-α4β1 integrin (HP2/1), implying that the interaction between VCAM-1 and α4β1 integrin may play an important role in RA synovium [58]. Here, VCAM1 is linked to rheumatoid arthritis.