For example, Garmy-Susini et al. first observed that VCAM-1 and α4β1 integrin were individually expressed on vascular smooth muscle cells and endothelial cells in the developing vessels of breast cancer, and found that the administration of an anti-murine VCAM-1 antibody (M/K-2) specifically reduced microvessel formation in Matrigel plug mouse models [111]. Here, VCAM1 is linked to breast carcinoma.