VCAM1 and hemangioma: In other studies, α4β1 integrin-transfected K562 erythroleukemia cells exhibited tethering and rolling in a VCAM-1-coated flow chamber with TNFα-stimulated HUVEC monolayers, and the siRNA-mediated knockdown of VCAM-1 in subcutaneous hemangioma endothelial cells (sEnd1) reduced the adhesion of Jurkat T cells to monolayers of sEnd1, demonstrating the importance of the interaction between α4β1 integrin and VCAM-1 in inflammation [27,37].