CDKN1C and Beckwith-Wiedemann syndrome: Genetic and epigenetic disorders in the imprinted region 11p15 and CDKN1C mutations can lead to embryonic abnormalities, such as those occurring in Beckwith-Wiedmann syndrome (BWS; OMIM 130650), IMAGe syndrome (OMIM 614732) and Russell–Silver syndrome (RSS-OMIM 180860) and acquired diseases such as cancer.