CDKN1C and cancer: Moreover, many authors have attributed to the p57Kip2 levels a value of prognostic marker since a decrease of its expression has been correlated to a poor prognosis [153,155] As described above, different epigenetic and genetic mechanisms can modulate the expression of CDKN1C. Essentially, loss of imprinting, DNA methylation and post-translational modifications of histones in the promoter region as well microRNAs downregulate CDKN1C in human cancers.