CDKN1C and neoplasm: Consistently with the importance of DNA methylation not only in paternal allele imprinting but also in p57Kip2 expression modulation in specific cellular and cell cycle phase contexts, treatment of many human tumor cell lines with demethylating agents such as 5-azacytidine and 5-aza-2′-deoxycytidine results generally in p57Kip2 expression activation [102,104].