CDKN1C and neoplasm: Furthermore, a glucocorticoid response element is located 5076 to 5062 bases upstream of the transcription start site of the human CDKN1C gene and is responsible for the glucocorticoid inducibility of the CDKN1C gene [86], thus explaining, at least in part, the antiproliferative effect of dexamethasone in human tumor cells such as Hela cell line [87].