Moreover, inhibiting PKD1 by the application of a protein kinase inhibitor such as Staurosporine, or by the knockdown of PKD1 through infection of PKD1 shRNA does not affect the regulated NMDAR endocytosis but prevent NMDAR endocytosis-induced phosphorylation and inhibition of remaining NMDARs [25,26]. Here, WEE1 is linked to infection.