Single-cell RNA-seq data of three melanoma short-term cultures of BRAF/NRAS double wild type (wt/wt), BRAF-mutant/NRAS-wild type (BRAF-mut/NRAS-wt) and BRAF wild type/NRAS-mutant (BRAF-wt/NRAS-mut) cells were analyzed regarding PT dynamics to assess mechanisms of tumor progression. This evidence concerns the gene NRAS and melanoma.