Treatment with Ruxolitinib resulted in reduction of multiple cytokines, including C-reactive protein (CRP), IL-1RA, macrophage inflammatory protein 1β (CCL4), TNFα, and IL-6 in PMF patients coincident with symptom improvement, further providing a link between inflammatory cytokines and symptom burden in MPN [9] (Figure 2). The gene discussed is CRP; the disease is myeloproliferative disorder.