ACE and hypertensive disorder: For instance, diabetic patients who have hypertension and kidney disease may be given perindopril (angiotensin-converting-enzyme inhibitor) that could increase sRAGE levels (Forbes et al., 2005), while the patients with hypercholesterolaemia may be prescribed with statins that could increase the activities of enzymatic antioxidants (Davignon, Jacob & Mason, 2004).