The D-CKD patients with poor GC, D-CKD patients with good GC and ND-CKD patients exhibited significantly lower SOD activities compared to DM patients with poor GC (P < 0.001), D-CKD patients with good GC (P < 0.001) and non-DM patients (P < 0.01) respectively. The gene discussed is SOD1; the disease is chronic kidney disease.