SYNE1 and Duchenne muscular dystrophy: It should be noted that it is very reasonable to use Duchenne muscular dystrophy (DMD) as a control, and although there is one report of a case study of a DMD patient with altered nuclear structure similar to LMNA related muscular dystrophy, further analysis showed this patient also carried a mutation in Nesprin-1, and patients with other mutations in dystrophin showed no significant differences in nuclear structure from non-disease human fibroblasts [10].