In agreement with their findings, Qi and coworkers found that the levels of SFRP1 mRNA expression were markedly reduced or silenced in colorectal carcinomas and adenomas compared with the normal mucosa, and the reduced SFRP1 expression was significantly associated with aberrant hypermethylation of the SFRP1 gene [8]. The gene discussed is SFRP1; the disease is adenoma.