Recently, we found that Dioscorea japonica extract (DJE) suppressed the expression of COX-2 and mPGES-1 in human non-small-cell lung carcinoma A549 cells and colon carcinoma Caco-2 cells, thereby inducing apoptosis in such cells.(11) DJE suppresses COX-2 mRNA with translocation of transcriptional factor nuclear factor-κB (NF-κB) to cytosol and a reduction of COX-2 promoter activity.(11). Here, PTGS2 is linked to colon carcinoma.