In combination of our in-house gastric cancer DNA methylation (450k) data (gastric cancer cell lines AGS, MGC803, MKN45, normal gastric tissue, and normal gastric epithelial GES1; data unpublished) and TCGA gastric cancer DNA methylation (450k) data, we found that ZNF471 is one the most significantly hypermethylated zinc-finger protein genes, with low mRNA expression in gastric cancer as compared with normal gastric tissue or tumor adjacent tissues (q value = 0.0003). The gene discussed is ZNF471; the disease is neoplasm.