Plasma from mice-bearing IRA-overexpressing tumors (Fig. 10b) contained more IRsol than plasma from mice-bearing tumors from native cells (Fig. 10c), while there was no difference in mice body weight (23.3 ± 2.9 g vs 22.2 ± 1.6 g), tumor volumes (1.23 ± 0.43 cm3 vs 1.26 ± 0.16 cm3), and BACE1 mRNA levels (1.0 ± 0.16 vs 1.05 ± 0.31). The gene discussed is BACE1; the disease is neoplasm.