Complementary, another group presented hypermethylation in several promoter regions—namely SFRP1 and SFRP2, SDC2 and PRIMA1—in CRC and adenomas.51 As previous described,16 hypermethylation seems to occur at a very early stage during CRC carcinogenesis and increases with progression. The gene discussed is PRIMA1; the disease is colorectal carcinoma.