CD274 and infection: Blocking of PD1/PDL-1 signaling did not affect body weight during the course of infection (Fig. 3A); however, treatment with anti-PDL-1 antibody resulted in effective clearance of parasites from the spleen and BM compared to the isotype control (P < 0.0001 and P = 0.003, respectively) (Fig. 3B and C).