A commercial lateral flow assay that uses polyclonal Abs raised against LAM to detect this Ag in the urine of TB-infected subjects (Alere Determine TB LAM Ag) has proven useful in diagnosing TB infection in HIV-coinfected patients with low CD4 counts (25, 27–30), and the use of this test allowed early detection and subsequent treatment that was associated with reduced mortality in such patients (31). This evidence concerns the gene CD4 and tuberculosis.