In present study, after restoration of TGFBI expression in L02 cells with stably transfected pHBV4.1-HBs(sW172*), the tumor volume was significantly reduced in nude mice; and the expression of CyclinD1 decreased in L02 cells accompanied by a decreasing of cell proliferation and increasing of cell apoptosis(data unshown). The gene discussed is CCND1; the disease is neoplasm.