We further found that SGK1 inhibition-induced metastasis suppression function is dependent on its negative regulation on the EMT, at least partially through autophagy induction, as its deletion could confer resistance to Snail-induced EMT but in contrast its overexpression could attenuate autophagic activity and promote the EMT and metastasis in PCa. This evidence concerns the gene SNAI1 and posterior cortical atrophy.