Our findings showed that SGK1 exhibited a significant upregulation in primary metastatic PCa tissues, and downregulation of SGK1 could induce autophagy, which contributes to suppress metastasis and reverse the EMT through the downregulation of Snail, whereas its overexpression could attenuate autophagic activity and promote the EMT and metastasis in PCa. The gene discussed is SGK1; the disease is posterior cortical atrophy.