Here we demonstrated that SGK1, a common downstream mediator of androgen receptor (AR) and glucocorticoid receptor (GR) signaling pathways [17], which displayed a significant upregulation expression in primary metastatic PCa tissues, could act as a tumor metastasis promoting gene in prostate cancer, as evidenced by its downregulation could suppress PCa cell lines invasion and migration capacity, whereas its overexpression could promote metastasis. This evidence concerns the gene NR3C1 and posterior cortical atrophy.