As shown in Fig. 4a, pharmacological inhibition of MYC or β-catenin dramatically decreased the expression level of MYC detectable by Western blots, and significantly reduced the luciferase activity in RU cells stimulated with H2O2. When we performed siRNA to knockdown Sox2 in RU cells from both ALK+ALCL cell lines, we found a significant decrease in the RU/RR conversion, as evidenced by the finding that the H2O2-induced increases in the luciferase activity were significantly attenuated (Fig. 4b). The gene discussed is ALK; the disease is anaplastic large cell lymphoma.