In our prior studies of ALK+ALCL, we had identified two distinct cell subsets in ALK+ALCL based on their differential response to a commercially available Sox2 reporter, which key components consist of the Sox2 regulatory region 2 (SRR2) as well as two gene reporters (Green Fluorescence Protein, GFP and Firefly luciferase) [9]. This evidence concerns the gene SOX2 and anaplastic large cell lymphoma.