These include MMP8, a metallopeptidase that contributes to extracellular matrix remodeling, NAALAD2, a peptidase that hydrolyses N-acetyl-aspartyl glutamate and glutamate and a marker of prostatic carcinomas, and ACVRL1, a receptor for TGF-β family of ligands. The gene discussed is ACVRL1; the disease is prostate carcinoma.