TPH2 and Sudden unexpected death in epilepsy: We used labelling for TPH2, the main synthesising enzyme of 5-HT, and labelling for its presynaptic transporter (SERT) and found evidence for a reduction in the medullary serotonergic systems in SUDEP, with preferential loss of TPH2 labelling in the VLM and SERT in the medullary raphe.