Body Mass Index (BMI) over 25 kg/m2 [42,44,45], or 35 kg/m2 [58,62], chronic heart [42,44,45,50–52,57,58,60–63], liver [56,60,63], or renal [42,42,45,56,58,60–63] failure, insulin treatment [47,51], uncontrolled T2DM [47], thyroid disorder [50,52], or treatment that can influence HRV parameters [44–46,52,54,57–60]. The gene discussed is INS; the disease is thyroid gland disorder.