In all, we found validation evidence supporting obesity phenotypes in mice for 10 of the 36 genes found in our fly validation screen of cis genes near human BMI loci (ZNF704, SETD1A, VTI1A, TCF7L2, FOXO3, NUDT2, PARK2, VASP, and YPEL3). The gene discussed is TCF7L2; the disease is obesity disorder.