Instead, our screen suggests that different nearby cis gene may be more fruitful for further functional follow up for obesity, namely ZCCHC8, VPS33A, RSRC2; SPDEF, NUDT3; SETD1, VKORC1; SGSM2, SRR; VASP, SIX5; OTX1; BANK1; ARIH1; ELL; CHST8, respectively. The gene discussed is VPS33A; the disease is obesity due to melanocortin 4 receptor deficiency.