TCF7L2 and obesity due to melanocortin 4 receptor deficiency: In all, we found validation evidence supporting obesity phenotypes in mice for 10 of the 36 genes found in our fly validation screen of cis genes near human BMI loci (ZNF704, SETD1A, VTI1A, TCF7L2, FOXO3, NUDT2, PARK2, VASP, and YPEL3).