PTPRD and endometrial cancer: While PTPRD is an attractive candidate gene for regulation by rs2475335, the gene targeted by this SNP (or equally by another SNP/s in high linkage disequilibrium with rs2475335) is as yet unknown, and further experimental studies in both endometriosis and endometrial cancer models are now required to investigate the biology underlying the increased risks of both diseases associated with this variant 44.