SKAP1 and endometrial cancer: For example, the missense variant rs2278868 located on chromosome 17q21.32 within exon 7 of the SKAP1 gene is in perfect linkage disequilibrium (r2 = 1) with rs1452666, which we have previously reported as having borderline GWAS significant association with endometrial cancer in the combined GWAS and iCOGS datasets 9.