Previously, our group has demonstrated a role for 5LO in the development of the AD‐like phenotype of APP transgenic mice and related tauopathy as well as the triple transgenic mice, which are known to develop both Aβ plaques and tau tangles (Chu, Giannopoulos, Ceballos‐Diaz, Golde & Pratico, 2012; Chu, Li & Pratico, 2013; Giannopoulos, Chu et al., 2014; Giannopoulos et al., 2015; Giannopoulos, Joshi & Praticò, 2014; Joshi, Chu & Praticò, 2013). The gene discussed is MAPT; the disease is tauopathy.