Both BL and PT severity of cannabis dependence (SDS) scores were negatively correlated with mean, maximum, and final week plasma CBD concentrations—the higher the plasma CBD, the lower the SDS score (rho range −0.43 to −0.72, p range 0.056 to 0.0003), with stronger associations at BL than at PT (Fig. 4), but change in severity of dependence was not correlated with plasma CBD concentration. The gene discussed is OPN1MW; the disease is cannabis dependence.