The expression of S100P (HR = 1.4, 95% CI: 1.02–1.93, and p = 0.0340) and S100B (HR = 0.47, 95% CI: 0.24–0.93, and p = 0.025) was modestly associated with OS in patients with grade II and III lung cancer, respectively. The gene discussed is S100P; the disease is lung cancer.