In NSCLC, several S100 family members (S100A2, S100A4, S100A7, S100A10, S100A11, and S100A16) have been shown to be related to poor prognosis in different studies [5, 11–13], although the role of the majority of S100 proteins in NSCLC has not been reported. The gene discussed is S100A10; the disease is non-small cell lung carcinoma.