AGT and diabetes mellitus: Compared with the infiltration of numerous inflammatory cells and fibroblasts in renal lesions induced by lipopolysaccharide (LPS) [40], cisplatin [41], high-fat diet [42], angiotensin II [43], diabetes [44], and so forth, renal lesions induced by MCT are characterized by renal microcirculation lesions such as glomerular tuft hypertrophy, mesangial expansion, phenotypic conversion of SMCs, and EndMT without an extensive inflammatory response.