In BD, important genetic variants that could be affected by shiftwork either directly or indirectly are Del, ANK3 rs1938526, COMT Val158Met, DAOA, BRD1/ZBED4, BDNF Val66Met, BRD1, ASMT, CAMTA1, CCDC132, CHES1, DGKH, DRD4, HTR1A C1019G, SLC6A4, 5-HTTLPR PARD3B, PDLIM5, STin2 VNTR, KLHL3, LYPD5, MAOA T941G, MTHFR A1298C and C677T, TPH1 STAB1, HTR3B, and WNK2 [95]. This evidence concerns the gene BRD1 and Behcet disease.