The ORR was 18.2% and median OS was 13.7 months for the entire cohort, while it is notable that patients positively tested for PD-L1 expression (5% or more tumor cells expressing PD-L1) showed a higher ORR of 53.8%, while only 4.2% of PD-L1 negative patients responded to treatment with avelumab 4.2%. Here, CD274 is linked to neoplasm.