We obtained fibroblasts from a patient homozygous for the TREM2 T66M mutation, associated with an FTD-like condition (Guerreiro et al., 2013b) (T66M/T66M), two unaffected family members carrying a single copy of the T66M mutation (wt/T66M), and a patient homozygous for the recently described TREM2 W50C mutation causal for NHD (Dardiotis et al., 2017) (W50C/W50C), and reprogrammed them to iPSCs. Here, TREM2 is linked to frontotemporal dementia.