KCNJ10 and amyotrophic lateral sclerosis: Downregulation of AS Kir4.1 has been observed in several CNS diseases such as acute and chronic neuroinflammation (Schirmer et al., 2014, Zurolo et al., 2012), spinal cord injury (Olsen et al., 2010), and transgenic mouse models of ALS (Bataveljić et al., 2012, Kaiser et al., 2006), raising the question of whether such dysregulation is pathological or maladaptive.