GH1 and acromegaly: As a result of the biological mechanisms underlying acromegaly, the most recent guidelines, by the Endocrine Society and the American Association of Clinical Endocrinologists (AACE), for the diagnosis and treatment monitoring in acromegaly focus on three key biomarkers; (a) IGF-1, (b) (mean) GH and (c) level of suppression of GH concentrations during an oral glucose tolerance test (OGTT), further referred to in this article as the biomarkers of interest [8, 9].