CD40LG and neoplasm: The GM2 ganglioside is a tumor‐associated carbohydrate antigen (TACA) detected at higher levels in malignant melanoma and other forms of cancer.50 Significant efforts have been made to develop tumor vaccines based on TACA targets including GM2.51 Clinical vaccination studies with purified GM252 or GM2 conjugated to keyhole limpet hemocyanin (GM2‐KLH)53, 54 have shown variable induction of cytolytic anti‐GM2 IgM and IgG.