There is a significant loss of B4GALNT2 expression in colonic tumors compared to normal tissue.64 The reduction of B2GALNT2 expression often correlates with a change in promoter methylation 65, 66 and with an increase in the synthesis of sialyl Lewis antigens.60 The increase in sialyl Lewis antigens appears to result from the reduction in B4GALNT2 expression, which alters the balance of competition between B4GALNT2 and fucosyltransferases in colonic tumors for the same acceptor substrate.24 The gene discussed is B4GALNT2; the disease is colonic neoplasm.