In total, among 206 endometrial and/or colorectal cancer driver genes examined in the cases from the combined endometrial and colorectal cancer cohorts, 50% (1065/2118) of those in POLE‐mutant samples had a POLE signature score of >0, as compared with 14% (628/4427) in MMR‐D and MMR‐P cancers (p < 1 × 10–26). The gene discussed is POLE; the disease is cancer.