POLE and cancer: Strikingly, in POLE‐mutant tumours, almost all known cancer driver genes showed evidence of the POLE consensus mutational signature, with the notable exception of POLE itself (Figures 3 and 4; supplementary material, Tables S8–S10 and Figures S4 and S5), consistent with the postulate that the POLE signature is a direct effect of the polymerase proofreading mutation.