For example, in sporadic colorectal cancer – a tumour type in which the molecular progression of precancers (adenomas) to invasive carcinomas has been well characterized – mismatch repair deficiency (MMR‐D) or chromosomal instability occur after initiating (epi)mutations in APC, BRAF, or KRAS, or other events such as whole genome doubling or loss of chromosome 18q 19, 20, 21, 22, 23, 24. The gene discussed is APC; the disease is neoplasm.