Microdissection and targeted sequencing of these lesions by use of a 30‐gene molecular inversion probe capture NGS panel (supplementary material, Table S3), a custom 80‐gene Ion Ampliseq Cancer Hotspot panel (supplementary material, Table S4) and Sanger sequencing revealed that, in all cases, the POLE mutation present in the carcinoma was also detectable in the paired precursor (Figure 1A,B; supplementary material, Table S7). The gene discussed is POLE; the disease is carcinoma.