Analysis of our combined cohort with this pipeline confirmed that POLE‐mutant colorectal cancers harboured a substantially greater number and density of predicted clonal neoantigens (0.12/Mb) than tumours lacking POLE mutations, including both MMR‐P cases (0.0029/Mb; p = 0.0002, Mann–Whitney U‐test) and hypermutated MMR‐D cases (0.044/Mb; p = 0.03) (Figure 6; supplementary material, Figure S11). The gene discussed is POLE; the disease is neoplasm.