Consistent with this prediction, all POLE‐mutant EINs showed a prominent CD8+ infiltrate (Figure 5A), which was significantly greater than that in POLE‐wild‐type EINs (median 59.4 versus 14.8 CD8+ cells per HPF; p = 0.029, Mann–Whitney U‐test), and exceeded that observed in the POLE‐wild‐type endometrial carcinomas, although this difference was not statistically significant (median 59.4 versus 24.7 CD8+ cells per HPF; p = 0.11) (Figure 5B). Here, POLE is linked to endometrial carcinoma.