MBD2 and colitis: At 30 days, 83% (5/6, p = 0.002) of Mbd2−/− mice showed continuing signs of colitis which included severe mucosal inflammation with severe diarrhoea, widespread crypt loss, superficial ulceration, focal active cryptitis with scattered crypt abscesses, and patches of epithelial regeneration (Figure 4B and supplementary material, Figure S4A).