Previous research demonstrated that EGFR is expressed in more than 90% of HNSCC and that high EGFR expression is correlated with worse outcomes (Ang et al., 2002; Cohen, 2006; Dassonville et al., 1993; Rubin Grandis et al., 1996, 1998; Santini et al., 1991). Here, EGFR is linked to head and neck squamous cell carcinoma.