The significant increase in ΔMFI of EGFR‐positive cells under hypoxia was detected in cetuximab‐sensitive and intrinsically cetuximab‐resistant as well as acquired cetuximab‐resistant and PBS‐treated HNSCC cell lines (P ≤ 0.018) (Fig. 3B). Here, EGFR is linked to head and neck squamous cell carcinoma.