BDNF and early-onset autosomal dominant Alzheimer disease: Using all 874 overlapping transcripts as input into DAVID [73], the top KEGG pathways were found to include MAPK, Wnt, calcium, phosphatidylinositol, neurotrophin, and TGF-beta signaling pathways, as well as long-term depression, axon guidance, long-term potentiation, and Alzheimer’s disease (Fig. 5b; all p < 0.05).